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Smite is an online battleground between mythical gods. Players choose from a selection of gods, join session-based arena combat and use custom powers and team tactics against other players and minions. Smite is inspired by Defense of the Ancients (DotA) but instead of being above the action, the third-person camera brings you right into the combat. And, instead of clicking a map, you use WASD to move, dodge, and fight your way through the detailed graphics of SMITE's battlegrounds.
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Traveler's Shoes, Pythagorem's Piece, Sovereignty, Heartward Amulet, Pridwen, situational (e.g. Relic Dagger or Emperor's Armour). Sell boots lategame for Lono's Mask or Bumba's Mask or Staff of Myrddin or other.
Alternatively, go: Shoes of Focus, Gauntlet of Thebes, Jade Emperor's Crown, Void Stone/ Genji's Guard, Pridwen, situational. Sell boots lategame for Lono's Mask or Staff of Myrddin or Bumba's Mask or other.
I think best idea would be to ask EmilZy on his twitch stream or youtube comments what an Isis support build could be.
Also ideally you only need 20 to 30% CDR in a Isis build since her passive gives 10% CDR, and Potion of Magical Might also gives 10% CDR as well.