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This build helps you get doom orb early. Since you don't have an escape, doom orb will be very helpful.
Mage's Blessing
Lost Artifact
Mana Potion
Healing Potion
Here is an example of a full build for Nu Wa mid. If you are up against healers or heavy lifesteal users, switch Spear of Desolation for Divine Ruin. If the enemies are building a lot of HP, switch Obsidian Shard for Soul Reaver.
Mage's Blessing
Shoes of Focus
Doom Orb
Spear of Desolation
Soul Gem
Obsidian Shard
Rod of Tahuti
If you find yourself needing to build some defense, these are good choices. I would build this later on though, if you build defenses early it will throw off your power spike and give you a weak mid game.
Breastplate of Valor
Void Stone
Mantle of Discord
Ethereal Staff
You pretty much always want to get these two relics.
Purification Beads
Aegis Amulet
Tap each threat level to view Nu Wa’s threats
When using Nu Wa's fog, don't stand in the middle or the farthest edge away from the enemy. They'll expect that and can aim and hit you still. Stay to the sides and other less expected places so they truly won't know where you are.
With her 2-3 combo, hit the enemy with both the explosion AND the 3. If it's just the explosion they'll be stunned but only take a little bit of damage. If you hit them with the explosion AND the shard, they'll be stunned and take a hell of a lot damage.
Nu Wa's ultimate has many uses! The most obvious is to use it to pick low health enemies escaping. However, using it at the start of a battle can turn the tides in your team's favor, as it will make the enemy team start the fight on lower health and can apply item effects such as antiheal immediately. It's also a great ward, since it reveals the whole enemy team! If you're in danger, it can also be used as a CC immunity/escape tool. You'll move forwards a bit, but you go up into the air and become untargetable for a couple seconds, hopefully enough to get team assistance or to get to safety.
And her passive, oh boy. This is the big difference between good Nu Wa players and bad Nu Wa players. Her passive, while simple, should not be taken lightly. It's a root on (basically) every 6th basic attack, and is especially strong early game if your jungler is ganking. Learn to land this root, it will separate you from the bad Nu Wa players.
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That said, Kriega, note that both Divine and Reaver are mentioned in the notes for the full build example. They say basically to switch Deso for Divine if anti-heal needed, and switch Ob Shard for Reaver if enemies have lots of HP.
Bad Luck, IMO you would probably want to keep Ob Shard, instead switching out Tahuti for Reaver as an option. You don't have enough % pen otherwise as Ob Shard is your only % pen.