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Transcendence as the first item because of the damage + flat pen increase, which is necessary if you want to maximize your damage output for the mid/late game stage.
We rush Transcendence as the first item because of the damage + flat pen increase, which is necessary if you want to maximize your damage output for the mid/late game stage.
Bumba's Cudgel
Axe
Health Potion
Blink Rune
This build offers high burst damage to take out your foes and offers 45 cooldown rate which adds up to be exactly 31.03% cooldown reduction with the formula
CDR% = (1 - (100 / (100 + CDRate))) Ă— 100
Bumba's Hammer
Transcendence
Hydra's Lament
Heartseeker
The Crusher
Titan's Bane
Tekko-Kagi
Blink Rune
Brawler's Ruin is a good pickup into the build if you need anti-heal, and I would recommend replacing 
Tekko-Kagi for the item. Brawler's Ruin is a good pickup into the build if you need anti-heal, and I would recommend replacing Tekko-Kagi for the item.
This also applies to any other item in the optional items.
Brawler's Ruin
Oath-Sworn Spear
Avatar's Parashu
Sundering Arc
Y
B
A
X
Tap each threat level to view Loki’s threats
Tap each synergy level to view Loki’s synergies
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Passive -
 Behind You! Loki deals bonus damage when hitting enemies from behind. Behind You! fits his stealth assassin theme, and is very powerful if enemies decide to run away, as you will deal much more damage than normal. Use  Vanish to get close and get a free hit from behind the enemy.
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Ability 1 -
Vanish Loki turns invisible, and his next auto attack applies a considerable damage-over-time effect Vanish is used to engage and disengage from fights. Use it every time an enemy god is near.There is a audio cue when you use the ability, so nearby enemies may be aware of your approach. The range of the audio cue is a little bit longer than auto attack range, presume if they could hit you before you used Vanish, they could hear you use Vanish.
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Ability 2 -
 Agonizing Visions Loki summons a vision, dealing light damage overtime to all enemies within a big radius. Enemies hit deal reduced damage, and if they are hit 4x they become blinded, while also allowing Behind You! to work from any direction Agonizing Visions is used to disorient enemies. It doesn't deal much damage on its own, but will reduce their damage dealt. It is also a good way to stop enemy blinks.
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Ability 3 -
 Flurry Strike Loki strikes 5x in a short cone in front of him, with a final 6th swing for extra damage. He's knockup immune while channeling, and slows enemies hit. Flurry Strike is your main damage ability, as it does a massive amount of damage over time. Use this to clear camps and damage gods in the early game. Once you are in the late game, use the ability less as your auto attacks will deal more damage.
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Ultimate -
 Assassinate Loki teleports to a location. If a god is in the radius, Loki will slice and cripple them, dealing damage. He will then slice one more time which can cleave nearby enemies, dealing extra damage and stunning them. Assassinate is your finishing move, used to lockdown an enemy or catch up to their location. You could also use it to escape from combat in a pinch, it has flexible usage.
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Vanish > Auto Attack > Flurry Strike > Auto Attack > Agonizing Visions > Auto Attack Vanish > Auto Attack > Agonizing Visions > Auto Attack Flurry Strike for the slow, but cancel it immediately after one strike. Vanish > Auto Attack > Agonizing Visions > Auto Attack > Assassinate > Auto Attack Assassinate, this attack chain deals the most amount of damage late-game. You risk enemies collapsing on you if Assassinate is down, so only do this when it's a 1v1 or you can confirm a kill. Flurry Strike can be used in the late game, but you should cancel it immediately, as we only use it as an auto attack reset at this stage of the game.
Loki has a lackluster early fight. Don't fight the enemy, use your abilities to clear the minions if you can do so safely. Your fights are based off of ambushes and out rotations, and there's no ambush if the enemy jungler is face to face with you. Assassinate, as it can force relics, if not kill the opponent. Vanish to get close. Your target should be the enemy backline, ideally a mage. If the enemy jungler lacks a form of CC immunity, you could try to hit them instead, as Assassinate will force their relics out. Agonizing Visions to farm minion waves without being seen by the enemies. You are strong at catching enemies out of position, and proper use of Vanish goes a long way. Do your best to avoid common ward areas, they are your biggest counter. Loki has a strong 1v1, but only if he can initiate first. Try pushing mid waves slowly and looking to bait out an enemy to clear it, save your Assassinate for the finisher or to escape if things turn bad. Vanish ends and you are within range, they will almost always 
Blink Rune onto you, which is dangerous.
Loki is a bunch of fun, but his reputation is there for a reason. It's important you play confidently in your solo plays, as he is not a character known for his team fight. The recommended build above should help out with this weakness, while still making your 1v1 strong. Everyone hates playing against an experienced Loki player, as they feel like there's no counter play. Live out your stealth assassin dreams!
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As a quick suggestion, could you also mention his aspect and your thoughts on it, along with use if it's something you situationally suggest? I'm pretty sure you would typically not use it...that decreased power in the 1 is tough and sharing the invis takes good planning/coordination...but would still be good to address!
Thank you for pointing that out. In the future, starting sometime today, I will have the pros and cons for each aspect of a god.
For Loki I wouldn't recommend using an aspect on him, and the reason is because of a couple of things.
reason #1: It hurts your damage too much due to the fact that it removes ALL DAMAGE from your 1, which makes it only useful if you're running Loki support, but the problem with that is you offer no pressure during the laning phase and on the map since your damage is too low to oppose a meaningful threat.
Reason #2: The range on his invisibility ability is too short to constantly make one of your teammates go invisible. The issue with that is that most of the time when you use your invisibility, you're not actually going to make any use of the fact that you can turn your teammates invisible because the range on the ability to apply such an effect is too short, and it will have to inconveniently go out of your way to apply this effect.
I could go on and on, but I would highly recommend NOT going the aspect on Loki, as it's overall not good in general and statistically.