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If enemy team have real strong heroes (aoe mage, solo target phys) need buy Breastplate of Valor or Pestilence 2-nd. Try buy through one dmg item with next defense item. If in battle you receive too much damage - 3rd item also buy defense. You need items with CDR, as fast as possible. Last item you can buy with according to your desire. If you buy 3-4 armor no need buy last item for damage.
Serqet need to be on left/right side in front. Enemies must always see you and be afraid of a blow from the side. When enemies attack the main group, you must attack the enemy's main enemy damager (like Zeus) and not let him deal damage. Provoke an enemy to hit you ultimate ability. No need attack solo. Attack the group together with the allies, and try to throw (ultimate) to them enemy that must be killed. You have much control with escape and you can't be killed.
Smite is an online battleground between mythical gods. Players choose from a selection of gods, join session-based arena combat and use custom powers and team tactics against other players and minions. Smite is inspired by Defense of the Ancients (DotA) but instead of being above the action, the third-person camera brings you right into the combat. And, instead of clicking a map, you use WASD to move, dodge, and fight your way through the detailed graphics of SMITE's battlegrounds.
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You can use builds from here for reference: https://smiteprobuilds.com/?p_filters_page=1&p_filters_search=&p_filters_god=2005&p_filters_pro=~&p_filters_opponent=~&p_filters_role=Support&p_filters_league=~&p_filters_sort=~
Im not 100% sure though about tank Serqet though you can follow what he EmilZy builds in this video for her: https://www.youtube.com/watch?v=xYiwM2us7gQ (The 2nd to last item would have been Ancile).