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Hand of the Gods if you wish to have faster clear speed.
You can forgo some potions and purchase Hand of the Gods if you wish to have faster clear speed.
Eye Of The Jungle
Mace
Healing Potion
Multi Potion
Blink Rune
Purification Beads
Eye Of The Jungle Deathbringer can be either upgrade. 
Envenomed Deathbringer if you are playing ADC style.
This build is your standard ADC build but with a variant using Eye Of The Jungle Deathbringer can be either upgrade. Envenomed Deathbringer if you are playing ADC style.
Protector Of The Jungle
The Crusher
Asi
Demon Blade
Silverbranch Bow
Envenomed Deathbringer
Temporal Beads
Corrupted Blink Rune
Spectral Armor The Crusher can be sold lategame for 
Bloodforge
This variant of the build is if your ADC is going crit and you think that the build path will be counterable by the enemy frontline with items such as Spectral Armor The Crusher can be sold lategame for Bloodforge
Protector Of The Jungle
The Crusher
Asi
Qin's Sais
Silverbranch Bow
The Executioner
Corrupted Blink Rune
Temporal Beads
Y
B
A
X
Tap each threat level to view Medusa’s threats
Tap each synergy level to view Medusa’s synergies
Acid Spray and Lacerate Medusa got more traction within Smite. Now before these changes Medusa was already strong so these changes ended up being more of a quality of life change for her. I have been asking for Lacerate to hit Minions for quite a while mainly for ADC as it gives her so much pressure but after her changes came along I decided to run her in jungle to see what kind of results I would get. I was pretty surprised at how oppressive and strong she actually functioned in Jungle. Especially in a bruiser meta where more DPS from hunters is always welcome.
Viper Shot atleast twice usually guarantees a kill with your other abilities but hitting all 4 shots can alone almost if not kill an enemy god 100-0. Lacerate is blockable the ability itself is fast and covers good distance to close gaps or escape. Lacerate and Petrify. A lot of the time Medusa can engage fights with Petrify as it will slow the enemies and allow her to set up her Viper Shot into Acid Spray and then follow up with Lacerate if you can kill them before they escape. Generally blinking on to the enemy and using Lacerate (when safe to do so) will force enemy movement. You can then use Petrify Which will reach every dash that matters. Viper Shot Will die so more lockdown on the team the better.
Dark Moon Shuriken and Viper Shot are ranged projectiles which do large amounts of damage. While Medusa needs to hit multiple she has range autos meaning overall there is more damage.
Silver Moon Caltrops is a weaker version of Acid Spray. While Silver Moon Caltrops has a slow Medusa makes up for that with the slow on Petrify
Kusarigama pretty straight forward. This and Lacerate both CC the enemy to setup the rest of the Gods abilities. Medusa does this better as hers can also act as movement and disengage while Tsukuyomi has no real mobility.
Screech and 
Vampire Bats both are required to hit to get most damage potential in a singular Camazotz combo. While Medusa is similar she has her own personal setup being Lacerate which Camazotz does not have. He must hit two skill shot abilities wheras Medusa is easier to confirm due to her root.
Bat Out of Hell Similarly to alot of ults. Ultimates provide cc immunity. Now while Camazotz has the better skill for that in comparison to Petrify The burst potential is in Medusa's favour without possibly putting herself out of position. So in terms of burst I feel Medusa is just a stronger Camazotz style God.
Piercing Moonlight While this ability does almost around twice the damage as Petrify it can only be used as cc immunity or an engage. Petrify on the other had has ranged damage and burst without fully committing to a fight and can also cc and slow down people engaging on Medusa therefore in my opinion making it stronger.
Lacerate on the other jungler who is trying to clear the minions and hopefully get some followup from the midlaner to kill them eventually snowballing in to an early game win. Blink Rune you should be looking to blink on to anybody away from the tower. Activate Viper Shot > Blinking > Viper Shot > Lacerate > Acid Spray > Viper Shot anybody who does not have their movement skill available will die to this. Lacerate. Start by activating Viper Shot . blinking > Viper Shot > Acid Spray (through minions if you can) Follow the enemy movement with Lacerate and finish off the rest of the Viper Shot Hits. This will guarantee you a kill at level 3. Blink Rune into Petrify is the perfect way to engage into lanes quickly especially when you aren't rotating in high. If you are able to find a path that is unwarded it is always best to flank behind enemies as you can save the majority of your abilities for when they react. Walking behind an enemy and auto attacking with or without Viper Shot generally is the easiest way to start an engagement. The enemy will only have so many options and normally this would be run to tower. At this point they will have dashed or jumped towards their tower and hopefully there is a wave coming. Medusa enjoys waves as she can spit Acid Spray into it to confirm hits to then follow up with Lacerate and Viper Shot. Starting engagements with Viper Shot can ruin some ganks as it will make a loud noise notifying them of your pressence so make sure you already have it active or wait until the engagement has started/they are rooted with Lacerate. Petrify from the enemy backline will make the enemy turn towards your team or allow your team to push forward. While this is a dangerous style you need to be aware of where the enemies are, where your team is and how you can get back to safety after engaging with a flank. Petrify. This generally will do some serious damage or make the enemy disengage. This allows your team to play up or get kills with ganks from your solo laner and mage followup. Lacerate > Viper Shot > Acid Spray will kill any squishy. even before the whole combo. Crit Medusa will kill within 2-3 critical hits. Don't be afraid to take your Red buff for these risky plays.
Manikin Scepter is useable but the mana sustain from Eye Of The Jungle is too good to give up. combine this with the late game stats from Protector Of The Jungle attack speed working with Silverbranch Bow with Viper Shot The attack speed to power conversion is huge.
The Crusher passive four times in each combo and that definitely plays a part in Medusa's high burst. This item first is generally better than other options such as 
Transcendence due to power spike and the penetration The Crusher provides.
The Crusher and the combined attack speed of your first 3 items and your Viper Shot Really makes Medusa a Menace to deal with at this stage in the game.
Viper Shot boosts attack speed by 80% giving massive value to Silverbranch Bow. The passive and while having penetration on the item it makes it perfect for this stage of the game. 30% Physical penetration and 30% flat penetration is allowing Medusa to hit incredibly hard.
Envenomed Deathbringer. The reason for this glyph is that this style of medusa is about our trading. The passive assists in doing so making it the smartest upgrade for this variation of build. 
Deathbringer is also also core in any build that has crit being built in my opinion. Qin's Saisand Envenomed Deathbringer with The Executioner. This build overall will be less DPS to squishies than the crit variation but generally this is the better build path when there is a lot of frontline and you are expecting Spectral Armor Which generally there will be especially when there are two hunters running crit.
Qin's Sais in this slot is because at this point in the game the majority of defences will be health. You have flat pen to help you out early in the build and now you will have Qin's Sais to melt Gods who buy items like
Sovereignty, 
Gauntlet of Thebes and 
Runeforged Hammer.
Qin's Sais variant is because frontline and tanky Gods are causing problems. The Executioner Will not only help you but also will help the other hunter on your team and your jungler and sometime even your solo laner so as a last item it is not a bad pickup. It also has synergy with Silverbranch Bow Deathbringer This time we are going for 
Malicious Deathbringer
Malicious Deathbringer is because we are planning on getting atleast one other crit item in this build and maybe a second if we get late enough. Malicious Deathbringer reduces the cooldown of skills when you crit so you want as much chance as you possibly can. Understanding this will help see why the next two items are alternatives for lategame.
Shadowsteel Shuriken also synergises with Acid Spray as you now have 90% antiheal. you have 70% crit at this stage so you have a good chance to get those crits in applying antiheal and reducing the cooldowns of your abilities with Malicious Deathbringer.
Fail-Not. Probably one of the most underbought items in my opinion but it is a bit of an awkward one to build. The item provides decent power, penetration, crit chance and cooldown. Ulting an enemy god will give you 100% crit chance in this build allowing you to quite freely dash in and get that cooldown back. Not only that the Cooldown on the item itself is pretty good for Medusa as she plays a lot around Petrify and Viper Shot
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